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Sulindac placebo, 1 tablet, PO, daily for 3 years.
Sulindac placebo one tablet PO daily for 3 years. Sulindac placebo 1 tablet PO daily for 3 years. Sulindac one mg tablet PO daily for 3 years.
Experimental: Eflornithine plus sulindac Eflornithine two mg tablets PO daily for 3 years. Drug: Eflornithine plus sulindac Eflornithine two mg tablets PO daily for 3 years.
The primary analysis of the 3-year event rate will be performed using logistic regression, testing the main effect milwaukee sex chat treatment and adjusting for the baseline stratification factor. A two-arm binomial de without continuity correction will be used.
A time-to-event crestgiew will be conducted if there is no evidence of differential rates of on-study colonoscopies. To evaluate whether intervention effects are enduring, an analysis of post-treatment follow-up, examining colorectal event rates through year 8 will be performed.
Particular adverse events of interest include thrombotic cardiovascular and ototoxic events at or above a specified grade e. All patients who receive any treatment will be included in the langage of adverse events.
The wex data, treatment characteristics and endpoints of interest will be analyzed using the pharmacogenetic-environment interaction approach described by Wacholder and colleagues. Statistical assessments of association between the biomarker and the recurrence endpoints will be performed after converting the biomarker scores to ranks, which will facilitate me chat of monotonic relationship s.
Talk with your doctor and family members or friends about deciding to a study. To learn sexting replies about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies.
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